Endocrine Abstracts

Background: The EarLy Surveillance for Autoimmune diabetes (ELSA) study is screening 20,000 children in the UK aged 3-13 years for type 1 diabetes through measurement of islet autoantibodies. Screening aims to prevent diabetic ketoacidosis at clinical onset of disease, reducing mortality, and identifies the population who could benefit from prevention trials. The ELSA-1 study aimed to explore the perspectives of parents and stakeholders on the relative benefit...

Objective: The EarLy Surveillance for Autoimmune diabetes (ELSA) study is screening 20,000 children aged 3-13 years for type 1 diabetes through measurement of islet autoantibodies. Screening aims to prevent diabetic ketoacidosis at clinical onset of disease and identifies the population who could benefit from prevention trials. The ELSA-1 study aimed to explore the perspectives of parents and stakeholders on the relative benefits and limitations of screening i...

Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming to delay disease onset. Teplizumab is the first immunomodulatory agent licensed in the US to delay the onset of T1D by 3 years in individuals at risk; a licensing decision is awaited in the UK. The EarLy Surveill...

Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming for immunoprevention. The EarLy Surveillance for Autoimmune diabetes (ELSA) study is exploring feasibility and acceptability of UK paediatric general population screening.Methods:</...

Background: General population screening for type 1 diabetes (T1D) using islet autoantibodies (IAb) is gaining international momentum, since screening reduces diabetic ketoacidosis, hospitalisation and identifies individuals eligible for future preventative treatments. Qualitative studies have only been undertaken in at-risk individuals (1). We therefore aimed to explore parents’ experiences of their child taking part in a general population T1D screening...